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Expert Rev Mol Med, 2001; 2001: 1-18. 26. Hood J. D. and Cheresh D. A. Role of integrins in cell invasion and migration. Nat Rev Cancer, 2002; 2: 91-100. 27. Colognato H. and Yurchenco P. D. Form and function: the laminin family of heterotrimers. Dev Dyn, 2000; 218: 213-234. 28. , Dalkin B. L. and Nagle R. B. Investigation into the mechanism of the loss of laminin 5 (alpha3beta3gamma2) expression in prostate cancer. Am J Pathol, 2001; 158: 1129-1135. 29. , Kunkel M. , Watts G. , Bowden G. , Cress A.

The central plaque contains adhesion molecules such as desmocollins, desmogleins and is an anchorage point for cytoskeletal filaments of the intermediate filament type (19). Desmogleins and desmocollins, adhesive transmembrane glycoprtoeins, constitute the subgroup of desmosomal cadherins (18). They are connected to the intermediate filament network of the cytoskeleton via associated cytoplasmic proteins such as the common plaque protein plakoglobin and several other cell type specific proteins including desmoplakins and plakophilins.

And Plass C. Aberrant CpGisland methylation has non-random and tumour-type-specific patterns. Nat Genet, 2000; 24: 132-138. 41. , Baylin S. B. and Herman J. G. Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients. Cancer Res, 1999; 59: 67-70. 41 42. , Corn P. , Baylin S. B. and Herman J. G. A gene hypermethylation profile of human cancer. Cancer Res, 2001; 61: 3225-3229. 43. , Fong K. , Virmani A. , Gazdar A. F. and Minna J.

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