By CIBA Foundation Symposium

Chapter 1 Photoperiodism, Melatonin and the Pineal: it is just a question of Time (pages 1–8): R. V. Short
Chapter 2 Mammalian Pinealocytes: Ultrastructural points and Innervation (pages 9–22): Lutz Vollrath
Chapter three Circadian Rhythms and Photoperiodism (pages 23–37): Martin C. Moore?Ede and Margaret L. Moline
Chapter four Photoneural legislation of the Mammalian Pineal Gland (pages 38–56): David C. Klein
Chapter five Melatonin and the mind in Photoperiodic Mammals (pages 57–77): M. H. Hastings, J. Herbert, N. D. Martensz and A. C. Roberts
Chapter 6 Eyes—the moment (and 3rd) Pineal Glands? (pages 78–92): Michael Menaker
Chapter 7 Photoperiodism in Birds (pages 93–115): B. ok. Follett, R. G. Foster and T. J. Nicholls
Chapter eight Photic affects at the constructing Mammal (pages 116–128): Steven M. Reppert, Marilyn J. Duncan and Bruce D. Goldman
Chapter nine iteration of Melatonin Rhythms (pages 129–148): G. A. Lincoln, F. J. P. Ebling and O. F. X. Almeida
Chapter 10 The position of Rhythms within the reaction to Melatonin (pages 149–169): Eric L. Bittman
Chapter eleven function of the Pineal Gland within the Photoperiodic regulate of Reproductive and Non?Reproductive capabilities in Mink (Mustela vison) (pages 170–187): Lise Martinet and Daniel Allain
Chapter 12 Melatonin management: results on Rodent Circadian Rhythms (pages 188–207): Stuart Maxwell Armstrong and Jenny Redman
Chapter thirteen The Pineal and Pubertal improvement (pages 208–230): Pierre C. Sizonenko, Ursula Lang, Robert W. Rivest and Michel L. Aubert
Chapter 14 Melatonin, gentle and Chronobiological problems (pages 231–252): Alfred J. Lewy, Robert L. Sack and Clifford M. Singer
Chapter 15 Melatonin and Affective problems (pages 253–265): Lennart Wetterberg
Chapter sixteen a few results of Melatonin and the regulate of its Secretion in people (pages 266–283): J. Arendt, C. Bojkowski, S. Folkard, C. Franey, V. Marks, D. Minors, J. C. Waterhouse, R. A. Wever, C. Wildgruber and J. Wright
Chapter 17 Melatonin and Malignant illness (pages 284–310): Lawrence Tamarkin, Osborne F. X. Almeida and David N. Danforth

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Extra resources for Ciba Foundation Symposium 117 - Photoperiodism, Melatonin and the Pineal

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J Androl5:64-69 Elliott JA 1976 Circadian rhythms and photoperiodic time measurement in mammals. Fed Proc 35~2339-2346 Elliott JA, Stetson MH, Menaker M 1972 Regulation of testis function in golden hamsters: a circadian clock measures photoperiodic time. Science (Wash DC) 178:771-773 Ellis GB, Turek FW 1980 Photoperiodic regulation of serum luteinizing hormone and folliclestimulating hormone in castrated and castrated-adrenalectomized male hamsters. Endocrinology 106:1338-1344 Everett JW 1942 Certain functional interrelationships between spontaneous persistent estrus, ‘light estrus’, and short-day anestrus in the albino rat.

Both phorbol esters and phenylephrine promote membrane association of protein kinase C in 46 KLEIN pinealocytes (Sugden et a1 1985b). The association of protein kinase C is thought to bring the enzyme in close association with a substrate, and in this manner to initiate phosphorylation of a membrane protein involved in regulating cyclic AMP generation. I I I I I A- I v , I I I I B A -1 FIG. 6. Potentiation of P-adrenergic cyclic nucleotide responses by phorbol esters (A, cyclic AMP; B, cyclic GMP).

Mammalian pineal function appears to be controlled primarily through the release of noradrenaline from the terminals of nerves whose cell bodies lie in the superior cervical ganglia. This is the final segment of the following neural pathway: retina- retinohypothalamic projection + suprachiasmatic nuclei + paraventricular nuclei + intermediolateral cell column + superior cervical ganglia + nervi conarii + pineal gland. Noradrenaline acts on pinealocytes through a- and p-adrenoceptors in an atypical manner.

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