By CIBA Foundation Symposium

Chapter 1 advent (pages 1–2):
Chapter 2 progress elements in Mammalian Embryogenesis (pages 3–22): John okay. Heath and Anthony R. Rees
Chapter three The EGF Receptor Kinase: proof for Allosteric Activation and Intramolecular Self?Phosphorylation (pages 23–45): Y. Yarden and J. Schlessinger
Chapter four position of progress components in Oncogenesis: progress Factor?Proto?Oncogene Pathways of Mitogenesis (pages 46–65): Jung San Huang and Shuan Shian Huang
Chapter five Signalling Mitogenesis in 3T3 Cells: function of Ca2+?Sensitive, Phospholipid?Dependent Protein Kinase (pages 66–86): Enrique Rozengurt, Angeles Rodriguez?Pena and James Sinnett?Smith
Chapter 6 The PDGF?Inducible ‘competence genes’: Intracellular Mediators of the Mitogenic reaction (pages 87–97): Megan Callahan, Brent H. Cochran and Charles D. Stiles
Chapter 7 Platelet?Derived development issue: Its power Roles in Wound therapeutic, Atherosclerosis, Neoplasia, and progress and improvement (pages 98–112): Russell Ross, Daniel F. Bowen?Pope and Elaine W. Raines
Chapter eight Nerve progress issue (pages 113–128): Hans Thoenen, Sigrun Korsching, Rolf Heumann and Ann Acheson
Chapter nine The function of Haemopoietic mobilephone development issue (Interleukin three) within the improvement of Haemopoietic Cells (pages 129–147): T. M. Dexter, C. M. Heyworth and A. D. Whetton
Chapter 10 Haemopoietic development elements: constitution and Receptor Interactions (pages 148–168): Antony W. Burgess
Chapter eleven In vivo results of the Insulin?Like development components (IGFs) within the Hypophysectomized Rat: comparability with Human development Hormone and the prospective position of the explicit IGF service Proteins (pages 169–187): J. Zapf, E. Schoenle and E. R. Froesch
Chapter 12 Protein Phosphorylation and development regulate (pages 188–205): Tony Hunter, Christopher B. Alexander and Jonathan A. Cooper
Chapter thirteen Receptors for the Phorbol Promoters Ester Tumour (pages 205–223): Peter M. Blumberg, Karen L. Leach, Bernhard Konig, Arco Y. Jeng and Nancy A. Sharkey
Chapter 14 Ectopic Peptides published through a Human cancer phone Line that Modulate the remodeled Phenotype (pages 224–240): Joseph E. De Larco and Dennis A. Pigott
Chapter 15 A progress Regulatory issue which can either Inhibit and Stimulate development (pages 241–269): Robert W. Holley, Julia H. Baldwin, Sybil Greenfield and Rosemary Armour

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5 mM-MgClz, 1mM-phenyl methyl sulphonyl fluoride (PMSF) and 1mM-EGTA) and incubated for 10min at 4 "C. The cellular lysate was briefly homogenized by three strokes with a glass Dounce homogenizer and further centrifuged. The pellet was discarded and the supernatant centrifuged for 30 min at 4 "C (40000g). 5, 150mM-NaC1, 1mM-EGTA and 10% glycerol) and loaded on a sucrose cushion (35% sucrose in phosphate-buffered saline). 5, and recentrifuged at 1OOOOOg for 20 min (4°C). The resulting pellet was resuspended and stored in aliquots at -70°C until used.

J Cell Physiol 122:l-6 Growthfactors in biology and medicine Edited by Ciba Foundation Copyright 0 1985 Ciba Foundation The EGF receptor kinase: evidence for allosteric activation and intramolecular self-phosphorylation ~ Y. YARDEN and J. SCHLESSINGER Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, Israel Abstract. The membrane receptor for epidermal growth factor is a transmembrane protein composed of an EGF-binding domain and a cytoplasmic kinase domain, connected by a single hydrophobic stretch.

7M-EGF for 15min at O'C, or to buffer only, and then immobilized on the corresponding agarose beads. 7 pM, 15min at OT), washed, and then phosphorylated. The phosphorylation reaction was allowed for 20s at 0°C. Receptor phosphorylation was determined by gel electrophoresis as described in Materials and methods. The values are receptor phosphorylation in the EGFtreated system before immobilization (left column) or after immobilization(right column), relative to the corresponding 'control' buffer-treated systems.

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