By Kiyohiro Houkin, Koji Abe, Satoshi Kuroda

This booklet provides finished reports for either translational examine and medical trials on telephone remedy for stroke.
Cerebral stroke remains to be a number one reason behind dying and incapacity. in spite of the fact that, regardless of in depth learn, few cures can be found. The healing capability of phone transplantation has been studied for numerous pathological stipulations of the vital anxious method (CNS) together with nerve-racking mind damage, stressful spinal twine harm, degenerative affliction, demyelinating illness and ischemic stroke, because the injured neural tissue within the CNS has just a restricted regenerative capacity.

Recently, a starting to be physique of facts during this box means that telephone transplantation holds nice capability as a kind of stroke therapy.
The authors, who're specialists within the box of neurosurgery, evaluation and talk about optimum telephone resources and diverse concerns excited by translational learn; extra, they define ongoing medical trials in Japan.

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Additional info for Cell Therapy Against Cerebral Stroke: Comprehensive Reviews for Translational Researches and Clinical Trials

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Neurobiol Dis. 2004;16(1):68–77. 016. 35. Zhang Q, Wu HH, Wang Y, Gu GJ, Zhang W, Xia R. Neural stem cell transplantation decreases neuroinflammation in a transgenic mouse model of Alzheimer’s disease. J Neurochem. 2015. 13413. 36. Pluchino S, Quattrini A, Brambilla E, Gritti A, Salani G, Dina G, et al. Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Nature. 2003;422 (6933):688–94. 1038/nature01552. 37. Feldman EL, Boulis NM, Hur J, Johe K, Rutkove SB, Federici T, et al.

Unique multipotent cells in adult human mesenchymal cell populations. Proc Natl Acad Sci U S A. 2010;107(19):8639–43. 54. Wakao S, Kitada M, Kuroda Y, Shigemoto T, Matsuse D, Akashi H, et al. Multilineagedifferentiating stress-enduring (Muse) cells are a primary source of induced pluripotent stem cells in human fibroblasts. Proc Natl Acad Sci U S A. 2011;108(24):9875–80. 2 Cell Therapy for Ischemic Stroke with Bone Marrow Stromal Cells 25 55. Yamauchi T, Kuroda Y, Morita T, Shichinohe H, Houkin K, Dezawa M, et al.

Kuroda Y, Kitada M, Wakao S, Nishikawa K, Tanimura Y, Makinoshima H, et al. Unique multipotent cells in adult human mesenchymal cell populations. Proc Natl Acad Sci U S A. 2010;107(19):8639–43. 54. Wakao S, Kitada M, Kuroda Y, Shigemoto T, Matsuse D, Akashi H, et al. Multilineagedifferentiating stress-enduring (Muse) cells are a primary source of induced pluripotent stem cells in human fibroblasts. Proc Natl Acad Sci U S A. 2011;108(24):9875–80. 2 Cell Therapy for Ischemic Stroke with Bone Marrow Stromal Cells 25 55.

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