By Carlos A. Zarate Jr., Husseini K. Manji
Even if our wisdom of temper problems ordinarily is increasing gradually, relatively little is understood approximately bipolar melancholy specifically. This ebook brings jointly best clinicians and preclinical and scientific researchers to supply the main updated information regarding the analysis, therapy, and study surrounding bipolar melancholy. Early chapters offer invaluable diagnostic info, and overview the direction, end result, and genetics of this hugely heritable , permitting clinicians to differentiate among a few of the temper problems. The ebook deals a radical and specific evaluation of the neurobiology of the sickness, together with what's identified from contemporary neuroimaging paintings. a number of chapters delineate the therapy of bipolar melancholy in designated populations reminiscent of kids and pregnant ladies, and one other bankruptcy addresses the actual problems with suicide, concentrating on the necessity for evaluate in the course of either acute and upkeep therapy with interventions acceptable to a patient's signs and background. eventually, the booklet covers acute and long term therapy options for bipolar melancholy, together with either conventional and novel therapeutics for the affliction, in addition to non-pharmacological remedies. This booklet has assembled a greatly revered workforce of preclinical and scientific researchers who convey their services to endure upon this disease. It bargains researchers, clinicians, and postgraduate scholars key insights into this devastating disease.
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Additional info for Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis and Pharmacotherapy (Milestones in Drug Therapy)
Co-morbid anxiety disorders may also elevate risk for suicidal ideation and attempts . The rates of mixed depression among bipolar and non-bipolar depressive suicide attempters is much higher than previously reported among non-suicidal Bipolar II and unipolar depressive outpatients, suggesting that suicide attempters come mainly from mixed depressives who Course and outcome of bipolar disorder – focusing on depressive aspects 33 have predominantly Bipolar II disorder . Recent findings show that while modest changes in severity of depression are associated with statistically and clinically significant changes in functional impairment and disability in patients with bipolar disorder, changes in severity of mania or hypomania are not consistently associated with differences in functioning .
When the rank order of the 32 symptoms (returned by the unipolar melancholic and unipolar non-melancholic groups respectively) was compared, analyses indicated that bipolar patients’ prioritising of characteristic symptoms was slightly closer to those with unipolar melancholia than to unipolar nonmelancholic depression. B. Parker and K. Fletcher sion. , brain feeling foggy, thinking slowed). A synthesis and some speculation Findings regarding bipolar depression, and in particular as reviewed by Mitchell and colleagues , suggest that those with BPD (compared to those with unipolar depression) are more likely to have a family history of BPD, somewhat briefer episodes of depression, and to report depressive symptoms that are generally compatible with melancholic and psychotic depression.
This is particularly true in bipolar disorder. In this chapter the authors summarize the main factors predicting course and outcome in bipolar disorder with a focus on depressive symptoms. The natural course, the impact of first episode, the impact of depressive phase, cycle length, onset, age, gender, type of illness, personality traits and temperament, co-morbidity, family history, life events, and outcome features will be reviewed. Conceptual models and their prognostic value will be discussed as well.