By Professor Samuel Dales, Professor Beatriz G. T. Pogo (auth.)
This quantity, Biology of Poxviruses, marks our debut as editors of this popular sequence. We plan to proceed the culture of offering a discussion board for exten sive, serious reports of person virus teams, as exemplified by means of the current quantity. however the speed of discovery is accelerating so swiftly that we believe the necessity to provide an extra structure: volumes that comprise collections of shorter, topical reports on a gaggle of comparable topics. Such collections could lower throughout con ventional obstacles among virus teams, dealing, as an instance, with a partic ular point of virus-cell interplay. Admittedly, this new structure stretches the time period "monograph" past the authorized definition, yet we think that we should always pay that rate to take care of the usefulness of the sequence as a medium of medical conversation. each time attainable, we are going to enlist assistance from deputy editors to convey such col lections to fruition. As some time past, the editors and the writer will welcome feedback for issues and contributions.
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Additional resources for Biology of Poxviruses
1978), and the DNAse which acts on double stranded DNA at an alkaline pH (McAuSLAN, 1965). The DNA polymerase becomes manifest coincidentally with commencement of virus DNA formation, rises to a maximum by 4 hours and retains high activity for several more hours, even after shut-off of DNA synthesis (JUNGWIRTH and JOKLIK, 1965; GREEN and PINA, 1962). , 1969; MAGEE and MILLER, 1967). The virus-related DNA polymerase has been recovered from the cytoplasm of infected cells and purified to homogeneity (CHALBERG and ENGLUND, 1979).
1978). The precursor molecules are methylated but not polyadenylated and apparently are devoid of non-informational sequences or 'introns' related to the splicing process. One might, therefore, conclude that during immediate-early transcription, polycistronic RNA molecules are produced which become simultaneously cleaved, polydenylated and extruded from the core as functional, monocistronic mRNAs (PAOLETTI and LIPINSKAS, 1978). ). B. Early vs Late Transeription As was to be anticipated from the observed rapid shut-off of host protein synthesis, the polyribosomes formed after vaccinia infection contain virusspecified mRNA, identified initially by base-composition analysis (BECKER and JOKLIK, 1964), and originating undoubtedly from the virosomes or cytoplasmic "factories" (DAHL and KATES, 1970).
It has been 30 III. , 1972). Improved, new procedures for extracting molecules from virions rapidly and in high yield have been developed (PARKHURST and HEIDELBERGER, 1976). These procedures utilize detergents, reducing agents such as mercaptoethanol and either high concentrations of urea (HOLOWCZAK, 1976) or concentrated NaCI solutions to release the genome. , 1978), or it may be purified by ion exchange chromatography on hydroxyapatite columns (CABRERA and ESTEBAN, 1978). Nucleic acid hybridization analyses have shown that the poxvirus genome contains predominantly unique DNA sequences.