By Linda A. Felton, James W. McGinity
This hugely praised publication offers an in-depth research of actual and chemical houses and purposes of aqueous-based polymeric coatings-covering covered dosage types, movie defects, and polymer characterization. New chapters on plastisizers and their functions in pharmaceutical coatings, adhesion of polymeric movies to stable substrates, and the impact of pigments on houses of the polymeric coating structures are incorporated during this 3rd version. also, this name presents new fabric on polymer interactions with medicinal drugs and excipients and actual getting older of polymeric movies.
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Extra resources for Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms, 3rd Edition (Drugs and the Pharmaceutical Sciences)
Polymer emulsification process. US Patent 4,177,177, 1979. Ortega AM. Latices of Cellulose Polymers; Manufacture, Characterization and Applications as Pharmaceutical Coatings. D. dissertation, Purdue University, 1977. Wesseling M, Bodmeier R. Drug release from beads coated with an aqueous colloidal ethylcellulose dispersion, Aquacoat® or an organic ethylcellulose solution. Eur J Pharm Biopharm 1999; 47(1):33–38. Banker GS, Peck GE. The new water-based colloidal dispersions. Pharm Technol 1981; 5(4):55–61.
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Full-strength plasticized Aquacoat was used without humidification of inlet air. The ideal release profile should not exhibit time, temperature, or humidity dependence on short-term challenges, as shown in Figure 13. This example used low solids loading to maintain high humidity (no humidification of inlet air). Note that during this and the two preceding examples, the coating loading was simultaneously lowered from 4% to 3% to 2% to maximize the amount of drug released. Fully coalesced films of Aquacoat ECD provide significant release retardation, Figure 12 Effect of low-humidity coating and curing conditions on drug release (35% solids, TEC/ECD = 1:4, 3% weight gain).