By Frank J. Dixon (Ed.)

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As shown in Fig. 3, the differences in the two responses were more dramatic when high-affinity precursor cells were analyzed. In this case, all of the splenic B cells that expressed K-bearing anti-NP antibodies produced antibodies with relatively low affinity, whereas, in the sIg- pool, a substantial number of precursor cells yielded K-bearing antibodies of high affinity. Again, particularly because of the affinity dependence of the disparity between sIg- bone marrow precursor cells and mature splenic B cells, it is tempting to speculate that the elimination of high-affinity K-bearing NP-specific B cells during B cell maturation in Ighh mice is due to tolerance induction.

Among these antigens is PC, and, to date, extensive studies in numerous laboratories have led to the conclusion that mice with the CBA/N defect not only respond poorly to immunization with PC, but also have few, if any, mature splenic B cells that recognize PC (Klinman and Stone, 1983). , 1981). In an extensive analysis of PC-specific precursor cells in (CBA/N x BALB/c)F, male mice (Klinman and Stone, 1983), it was found that splenic B cells from these mice have an exceedingly low frequency of cells responsive to PC when conjugated to Hy and, as yet, none of these responses has been Type I anti-PC antibodies.

When clones of such cells were subjected to AB-MuLV virus transformation, some of these cells went on to express light chains and ultimately an immunoglobulin product. An analysis of the light chains rearranged by clones of B cells demonstrated that while different light chains were utilized, the choice of light chains for any given clone of heavy chain rearranged cells was somewhat restricted. The second issue of great importance to our understanding of B cell repertoire development and expression that remains relatively unex- 34 NORMAN R.

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