By F.J. Dixon, Henry G. Kunkel (Eds.)

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30 J. B. NATVIG AND H. G . KUNKEL subclasses, but so far without success. Too few IgD and IgE myeloma proteins are known to exclude subclasses. The total number of immunoglobulin heavy-chain C-region cistrons can probably be estimated to be not less than nine and probably not more than twelve to fifteen. For the light-chain C regions, there is only one K cistron known, and, for the A C regions, three cistrons are known. b. Order of Heauy-Chain Cistrons. The most likely interpretation of the Lepore type of IgG is a deletion type of hybridization.

Genetic markers of different classes. ,1969b). A summary of the immunoglobulin heavy-chain allotypes, listed according to the two nomenclatures commonly utilized, is shown in Table VI. This table also includes the subclass to which each antigen is restricted, It was unfortunate that this subclass distribution was entirely ignored in thc preparation of the “new” numbering nomenclature system. TABLE VI HIL\VY-CNAIN ALMTYPESA N D 1 h L A T I O N IMMUNOGLOBULIN CLASSESAND SUBCLASSES IMMUNOGLCIIIULIN Nomenclature New Gm markers 1 2 3 4 5 Original a X b w or b4 f b and b’ 6 C 7 8 r e P bn 9 10 11 12 13 14 15 16 17 1s 19 20 21 22 23 L4 by b3 b4 S t z Rouen 2 ltouen 3 Sail Francisco 2 g IgGl IgGl IgGl IgGl 1gg3 1gg3 IgGl 1gg3 1gg3 1gg3 1gg3 1gg3 1gg3 1gg3 IgGl IgGl ?

1970a,b). However, as for the different enzyme susceptibility of the IgG subclass molecules to give Fc fragments, there are also striking differences in the conditions for release of pFc’ fragment from intact molecules. , 1970a). The CH2 region has not generally been isolated readily as a separate fragment and is digested to smaller peptides under the conditions used to release pFc‘. However, Connell and Porter (1971) have recently described a technique for isolating a so-called Facb fragment which appears to contain the Fab fragment plus the CH2 region of Fc, but lacks CH3 (pFc’).

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