By Priv.-Doz. Dr. med. Rainer Haas, Dr. med. Ralf Kronenwett, Priv.-Doz. Dr. rer. nat. Georg Sczakiel (auth.)

This publication supplies an outline of the present cutting-edge in peripheral blood stem telephone transplantation and up to date advancements in molecular prognosis and gene healing ways. the focal point is at the function of peripheral blood stem cellphone transplantation within the remedy of hematological malignancies comparable to non-Hodgkin lymphomas, continual myelogenous leukemia and a number of myeloma. present molecular organic thoughts for detecting genetic defects in tumors and minimum residual illness also are provided. extra subject matters contain new gene healing ideas in hematology and oncology: using viral vectors for transduction of hematopoietic cells is mentioned in addition to healing techniques in keeping with antisense nucleic acids, ribozymes, and immunological approaches.

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A retrospective analysis by the European Group for Bone Marrow Transplantation (EBMT) apparently showed different results (Sweetenham et al. 1995). Among the 214 patients reported in the registry, 105 were transplanted in first CR and the 6-year actuarial survival was 63%. Transplantation in second CR resulted in a 31 % rate of actuarial survival. These results seem better than those reported for a conventional-dose salvage regimen. In evaluating any chemotherapy series, these poor-prognosis patients must be differentiated from the remainder, who do remarkably well, with over 80% disease-free survival using conventional chemotherapy with standard multiagent-type therapy.

References Allan NC, Richards SM, Shepherd PC (1995) UK Medical Research Council randomised, multicentre trial of interferon-alpha n 1 for chronic myeloid leukaemia: improved survival irrespective of cytogenetic response. The UK Medical Research Council's Working Parties for Therapeutic Trials in Adult Leukaemia. Lancet 345:1392-1397 44 A. Hochhaus et al. Bartram CR, Bross Bach U, Schmidt H, Waller HD (1987) Philadelphia-positive chronic myelogenous leukemia with breakpoint 5' of the breakpoint cluster region but within the bcr gene.

M 2 melphalan alone, because of previous spinal radiotherapy, reduced pulmonary diffusion capacity, or refusal to undergo TBI. Following high-dose conditioning therapy, PBPCs were reinfused without additional bone marrow or growth factor support. 5 DC, while amphotericin-B was added if there was documented fungal infection or persistent fever. 1 was maintained by ABO-matched platelet transfusions, and packed red blood cells were given when the hemoglobin level was less than 8 g/dl. Statistical Analysis The clinical and laboratory data from the patients were evaluated according to standard statistical methods using a commercially available computer program (Statistica for Windows, Stat Soft, Tulsa, Oklahoma, USA).

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