By Roger A. Barker, Neil Scolding, Dominic Rowe, Andrew J. Larner

The moment variation of A-Z of Neurological perform builds at the prior variation withrevised and up to date details in a excessive density yet simply obtainable structure to supply a brief and prepared reference for busy clinicians of all levels of expertise. Entries for particular neurological stipulations are uniformly established indicating: Pathophysiology; scientific beneficial properties; Investigations and analysis; Differential prognosis; therapy and analysis. Key references are brought up all through and all entries are pass referenced.

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Oligodendroglial tau filamentous inclusions (coiled bodies) are also seen. Immunohistochemistry suggests that AGD is a 4R tauopathy and, hence, akin to progressive supranuclear palsy and corticobasal degeneration. Clinically, argyrophilic grain disease is a dementing disorder but with more prominent behavioral features and less prominent memory problems than in AD. Hence, some authors consider it distinct from AD. Reference Ferrer I, Santpere G, van Leeuwen FW. Argyrophilic grain disease. Brain.

Distal vacuolar myopathy also described. May present in adulthood. Investigation As a general rule, biochemical diagnosis is usually straightforward due to the accumulation of metabolites proximal to the enzyme defect, which, being water-soluble, may be detected in plasma and urine. References Charnas LR, Luciano CA, Dalakas M, et al. Distal vacuolar myopathy in nephropathic cystinosis. Ann Neurol. 1994;35:181–188 Evans OB, Parker CC, Haas RH, Naidu S, Moser HW, Bock H-GO. Inborn errors of metabolism of the nervous system.

The differential diagnosis is broad: • • • • • • • • • • • • • • • Partially treated bacterial meningitis Viral meningitis or meningoencephalitis Tuberculous meningitis Fungal meningitis Other bacterial/protozoal infections: brucellosis, lepto­spirosis, malaria Parameningeal infection: epidural/subdural abscess/empyema Chemical meningitis: blood (subarachnoid hemorrhage), myelographic agents Endocarditis Malignant meningitis: carcinoma, lymphoma, leukemia Venous sinus thrombosis Autoimmune disorders: vasculitis, Behçet’s disease, Sjögren’s syndrome Neurosarcoidosis Mollaret’s (recurrent) meningitis: dermoid, epidermoid Chronic (benign) lymphocytic meningitis Idiosyncratic drug reaction (intravenous immunoglobulin, NSAIDs) Aspergillosis This fungal infection (Aspergillus fumigatus) may present as a chronic sinusitis with skull base osteomyelitis, with ­involvement of cranial nerves adjacent to infected bone.

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